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Targeting Heparin to Collagen within Extracellular Matrix Significantly Reduces Thrombogenicity and Improves Endothelialization of Decellularized Tissues

Thrombosis within small-diameter vascular grafts limits the development of bioartificial, engineered vascular conduits, especially those derived from extracellular matrix (ECM). Here we describe an easy-to-implement strategy to chemically modify vascular ECM by covalently linking a collagen binding...

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Detalhes bibliográficos
Publicado no:Biomacromolecules
Main Authors: Jiang, Bin, Suen, Rachel, Wertheim, Jason A., Ameer, Guillermo A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5274546/
https://ncbi.nlm.nih.gov/pubmed/27936727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biomac.6b01330
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