Phospholipid flippases attenuate LPS-induced TLR4 signaling by mediating endocytic retrieval of Toll-like receptor 4

P4-ATPases are lipid flippases that catalyze the transport of phospholipids to create membrane phospholipid asymmetry and to initiate the biogenesis of transport vesicles. Here we show, for the first time, that lipid flippases are essential to dampen the inflammatory response and to mediate the endo...

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Detalhes bibliográficos
Publicado no:Cell Mol Life Sci
Main Authors: van der Mark, Vincent A., Ghiboub, Mohammed, Marsman, Casper, Zhao, Jing, van Dijk, Remco, Hiralall, Johan K., Ho-Mok, Kam S., Castricum, Zoë, de Jonge, Wouter J., Oude Elferink, Ronald P. J., Paulusma, Coen C.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2016
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5272906/
https://ncbi.nlm.nih.gov/pubmed/27628304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-016-2360-5
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