The marine-derived pachycladin diterpenoids as novel inhibitors of wild-type and mutant EGFR

Epidermal growth factor receptor (EGFR) is a key player in proliferation and metastasis of various cancers. Discovery of novel EGFR inhibitors is still an urgent clinical oncology unmet need. Pachycladins are eunicellin-based diterpenoids isolated from the soft coral Cladiella species. This study ev...

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Detaylı Bibliyografya
Yayımlandı:Biochem Pharmacol
Asıl Yazarlar: Mohyeldin, Mohamed M., Akl, Mohamed R., Siddique, Abu Bakar, Hassan, Hossam M., El Sayed, Khalid A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5272797/
https://ncbi.nlm.nih.gov/pubmed/27940262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2016.12.003
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