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The marine-derived pachycladin diterpenoids as novel inhibitors of wild-type and mutant EGFR
Epidermal growth factor receptor (EGFR) is a key player in proliferation and metastasis of various cancers. Discovery of novel EGFR inhibitors is still an urgent clinical oncology unmet need. Pachycladins are eunicellin-based diterpenoids isolated from the soft coral Cladiella species. This study ev...
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| Publicado no: | Biochem Pharmacol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5272797/ https://ncbi.nlm.nih.gov/pubmed/27940262 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2016.12.003 |
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