Blood pressure–associated polymorphism controls ARHGAP42 expression via serum response factor DNA binding

We recently demonstrated that selective expression of the Rho GTPase-activating protein ARHGAP42 in smooth muscle cells (SMCs) controls blood pressure by inhibiting RhoA-dependent contractility, providing a mechanism for the blood pressure–associated locus within the ARHGAP42 gene. The goals of the...

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Pubblicato in:J Clin Invest
Autori principali: Bai, Xue, Mangum, Kevin D., Dee, Rachel A., Stouffer, George A., Lee, Craig R., Oni-Orisan, Akinyemi, Patterson, Cam, Schisler, Jonathan C., Viera, Anthony J., Taylor, Joan M., Mack, Christopher P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5272192/
https://ncbi.nlm.nih.gov/pubmed/28112683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI88899
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