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Blood pressure–associated polymorphism controls ARHGAP42 expression via serum response factor DNA binding
We recently demonstrated that selective expression of the Rho GTPase-activating protein ARHGAP42 in smooth muscle cells (SMCs) controls blood pressure by inhibiting RhoA-dependent contractility, providing a mechanism for the blood pressure–associated locus within the ARHGAP42 gene. The goals of the...
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Publicado no: | J Clin Invest |
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Main Authors: | , , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
American Society for Clinical Investigation
2017
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5272192/ https://ncbi.nlm.nih.gov/pubmed/28112683 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI88899 |
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