The spleen microenvironment influences disease transformation in a mouse model of KIT(D816V)-dependent myeloproliferative neoplasm

Activating mutations leading to ligand-independent signaling of the stem cell factor receptor KIT are associated with several hematopoietic malignancies. One of the most common alterations is the D816V mutation. In this study, we characterized mice, which conditionally express the humanized KIT(D816...

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Xehetasun bibliografikoak
Argitaratua izan da:Sci Rep
Egile Nagusiak: Pelusi, Natalie, Kosanke, Maike, Riedt, Tamara, Rösseler, Corinna, Seré, Kristin, Li, Jin, Gütgemann, Ines, Zenke, Martin, Janzen, Viktor, Schorle, Hubert
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2017
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5269732/
https://ncbi.nlm.nih.gov/pubmed/28128288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep41427
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