The spleen microenvironment influences disease transformation in a mouse model of KIT(D816V)-dependent myeloproliferative neoplasm

Activating mutations leading to ligand-independent signaling of the stem cell factor receptor KIT are associated with several hematopoietic malignancies. One of the most common alterations is the D816V mutation. In this study, we characterized mice, which conditionally express the humanized KIT(D816...

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Detaylı Bibliyografya
Yayımlandı:Sci Rep
Asıl Yazarlar: Pelusi, Natalie, Kosanke, Maike, Riedt, Tamara, Rösseler, Corinna, Seré, Kristin, Li, Jin, Gütgemann, Ines, Zenke, Martin, Janzen, Viktor, Schorle, Hubert
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2017
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5269732/
https://ncbi.nlm.nih.gov/pubmed/28128288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep41427
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