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The spleen microenvironment influences disease transformation in a mouse model of KIT(D816V)-dependent myeloproliferative neoplasm

Activating mutations leading to ligand-independent signaling of the stem cell factor receptor KIT are associated with several hematopoietic malignancies. One of the most common alterations is the D816V mutation. In this study, we characterized mice, which conditionally express the humanized KIT(D816...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Pelusi, Natalie, Kosanke, Maike, Riedt, Tamara, Rösseler, Corinna, Seré, Kristin, Li, Jin, Gütgemann, Ines, Zenke, Martin, Janzen, Viktor, Schorle, Hubert
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5269732/
https://ncbi.nlm.nih.gov/pubmed/28128288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep41427
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