Antigen Exposure History Defines CD8 T Cell Dynamics and Protection during Localized Pulmonary Infections

Unlike systemic infections, little is known about the role of repeated localized infections on (re)shaping pathogen-specific memory CD8 T cell responses. Here, we used primary (1°) and secondary (2°) intranasal influenza virus infections of mice as a model to study intrinsic memory CD8 T cell proper...

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Udgivet i:Front Immunol
Main Authors: Van Braeckel-Budimir, Natalija, Martin, Matthew D., Hartwig, Stacey M., Legge, Kevin L., Badovinac, Vladimir P., Harty, John T.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2017
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5269565/
https://ncbi.nlm.nih.gov/pubmed/28191007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.00040
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