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Chemical and functional properties of metal chelators that mobilize copper to elicit fungal killing of Cryptococcus neoformans

A panel of iron (Fe) and copper (Cu) chelators was screened for growth inhibitory activity against the fungal pathogen Cryptococcus neoformans. Select bidentate metal-binding ligands containing mixed O,S or O,N donor atoms were identified as agents that induce cell killing in a Cu-dependent manner....

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Bibliographic Details
Published in:Metallomics
Main Authors: Helsel, Marian E., White, Elizabeth J., Razvi, Sayyeda Zeenat A., Alies, Bruno, Franz, Katherine J.
Format: Artigo
Language:Inglês
Published: 2017
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5269458/
https://ncbi.nlm.nih.gov/pubmed/27853789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6mt00172f
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