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Synthesis and Bioactivity of Diastereomers of the Virulence Lanthipeptide Cytolysin

Cytolysin, a two-component lanthipeptide comprising cytolysin S (CylL(S)″) and cytolysin L (CylL(L)″), is the only family member to exhibit lytic activity against mammalian cells, in addition to synergistic antimicrobial activity. A subset of the thioether crosslinks of CylL(S)″ and CylL(L)″ have LL...

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Foilsithe in:Org Lett
Main Authors: Mukherjee, Subha, Huo, Liujie, Thibodeaux, Gabrielle, van der Donk, Wilfred A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2016
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5269379/
https://ncbi.nlm.nih.gov/pubmed/27934350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.6b03246
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