Endothelial Cell-Specific Deletion of P2Y(2) Receptor Promotes Plaque Stability in Atherosclerosis-Susceptible ApoE-Null Mice

OBJECTIVE: Nucleotide P2Y(2) receptor (P2Y(2)R) contributes to vascular inflammation by increasing vascular cell adhesion molecule (VCAM)-1 expression in endothelial cells (EC), and global P2Y(2)R deficiency prevents fatty streak formation in ApoE(−/−) mice. Since P2Y(2)R is ubiquitously expressed i...

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Publicado no:Arterioscler Thromb Vasc Biol
Main Authors: Xingjuan, Chen, Qian, Shaomin, Hoggatt, April, Tang, Hongying, Hacker, Timothy A., Obukhov, Alexander G., Herring, Paul B., Seye, Cheikh I.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5268079/
https://ncbi.nlm.nih.gov/pubmed/27856454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.116.308561
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