Orally Administered Berberine Modulates Hepatic Lipid Metabolism by Altering Microbial Bile Acid Metabolism and the Intestinal FXR Signaling Pathway

Previous studies suggest that the lipid-lowering effect of berberine (BBR) involves actions on the low-density lipoprotein receptor and the AMP-activated protein kinase signaling pathways. However, the implication of these mechanisms is unclear because of the low bioavailability of BBR. Because the...

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Pubblicato in:Mol Pharmacol
Autori principali: Sun, Runbin, Yang, Na, Kong, Bo, Cao, Bei, Feng, Dong, Yu, Xiaoyi, Ge, Chun, Huang, Jingqiu, Shen, Jianliang, Wang, Pei, Feng, Siqi, Fei, Fei, Guo, Jiahua, He, Jun, Aa, Nan, Chen, Qiang, Pan, Yang, Schumacher, Justin D., Yang, Chung S., Guo, Grace L., Aa, Jiye, Wang, Guangji
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Pharmacology and Experimental Therapeutics 2017
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5267522/
https://ncbi.nlm.nih.gov/pubmed/27932556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.116.106617
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