G Protein–Coupled Receptor Endocytosis Confers Uniformity in Responses to Chemically Distinct Ligands

The ability of chemically distinct ligands to produce different effects on the same G protein–coupled receptor (GPCR) has interesting therapeutic implications, but, if excessively propagated downstream, would introduce biologic noise compromising cognate ligand detection. We asked whether cells have...

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Publicat a:Mol Pharmacol
Autors principals: Tsvetanova, Nikoleta G., Trester-Zedlitz, Michelle, Newton, Billy W., Riordan, Daniel P., Sundaram, Aparna B., Johnson, Jeffrey R., Krogan, Nevan J., von Zastrow, Mark
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Pharmacology and Experimental Therapeutics 2017
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5267521/
https://ncbi.nlm.nih.gov/pubmed/27879340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.116.106369
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