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HTP Nutraceutical Screening for Histone Deacetylase Inhibitors and Effects of HDACis on Tumor-suppressing miRNAs by Trichostatin A and Grapeseed (Vitis vinifera) in HeLa cells

Background/Aim: Aggressive tumor malignancies are a consequence of delayed diagnosis, epigenetic/phenotype changes and chemo-radiation resistance. Histone deacetylases (HDACs) are a major epigenetic regulator of transcriptional repression, which are highly overexpressed in advanced malignancy. While...

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Detalhes bibliográficos
Publicado no:Cancer Genomics Proteomics
Main Authors: MAZZIO, ELIZABETH A., SOLIMAN, KARAM F.A.
Formato: Artigo
Idioma:Inglês
Publicado em: International Institute of Anticancer Research 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5267498/
https://ncbi.nlm.nih.gov/pubmed/28031235
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