The FA Core Complex Contains a Homo-dimeric Catalytic Module for the Symmetric Mono-ubiquitination of FANCI-FANCD2

Activation of the main DNA interstrand crosslink repair pathway in higher eukaryotes requires mono-ubiquitination of FANCI and FANCD2 by FANCL, the E3 ligase subunit of the Fanconi anemia core complex. FANCI and FANCD2 form a stable complex; however, the molecular basis of their ubiquitination is il...

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Publicat a:Cell Rep
Autors principals: Swuec, Paolo, Renault, Ludovic, Borg, Aaron, Shah, Fenil, Murphy, Vincent J., van Twest, Sylvie, Snijders, Ambrosius P., Deans, Andrew J., Costa, Alessandro
Format: Artigo
Idioma:Inglês
Publicat: Cell Press 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5266791/
https://ncbi.nlm.nih.gov/pubmed/27986592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.11.013
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