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High-efficiency bypass of DNA damage by human DNA polymerase Q
Endogenous DNA damage arises frequently, particularly apurinic (AP) sites. These must be dealt with by cells in order to avoid genotoxic effects. DNA polymerase θ is a newly identified enzyme encoded by the human POLQ gene. We find that POLQ has an exceptional ability to bypass an AP site, inserting...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2004
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC526458/ https://ncbi.nlm.nih.gov/pubmed/15496986 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600424 |
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