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High-efficiency bypass of DNA damage by human DNA polymerase Q

Endogenous DNA damage arises frequently, particularly apurinic (AP) sites. These must be dealt with by cells in order to avoid genotoxic effects. DNA polymerase θ is a newly identified enzyme encoded by the human POLQ gene. We find that POLQ has an exceptional ability to bypass an AP site, inserting...

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Bibliografske podrobnosti
izdano v:EMBO J
Main Authors: Seki, Mineaki, Masutani, Chikahide, Yang, Lee Wei, Schuffert, Anthony, Iwai, Shigenori, Bahar, Ivet, Wood, Richard D
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2004
Teme:
Online dostop:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC526458/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15496986/
https://ncbi.nlm.nih.govhttps://doi.org/10.1038/sj.emboj.7600424
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