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High-efficiency bypass of DNA damage by human DNA polymerase Q

Endogenous DNA damage arises frequently, particularly apurinic (AP) sites. These must be dealt with by cells in order to avoid genotoxic effects. DNA polymerase θ is a newly identified enzyme encoded by the human POLQ gene. We find that POLQ has an exceptional ability to bypass an AP site, inserting...

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Hlavní autoři: Seki, Mineaki, Masutani, Chikahide, Yang, Lee Wei, Schuffert, Anthony, Iwai, Shigenori, Bahar, Ivet, Wood, Richard D
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2004
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC526458/
https://ncbi.nlm.nih.gov/pubmed/15496986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600424
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