Hypothalamic AMP-Activated Protein Kinase Regulates Biphasic Insulin Secretion from Pancreatic β Cells during Fasting and in Type 2 Diabetes

Glucose-stimulated insulin secretion (GSIS) by pancreatic β cells is biphasic. However, the physiological significance of biphasic GSIS and its relationship to diabetes are not yet fully understood. This study demonstrated that impaired first-phase GSIS follows fasting, leading to increased blood gl...

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Veröffentlicht in:EBioMedicine
Hauptverfasser: Kume, Shinji, Kondo, Motoyuki, Maeda, Shiro, Nishio, Yoshihiko, Yanagimachi, Tsuyoshi, Fujita, Yukihiro, Haneda, Masakazu, Kondo, Keiko, Sekine, Akihiro, Araki, Shin-ich, Araki, Hisazumi, Chin-Kanasaki, Masami, Ugi, Satoshi, Koya, Daisuke, Kitahara, Sawako, Maeda, Kiyosumi, Kashiwagi, Atsunori, Uzu, Takashi, Maegawa, Hiroshi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5264491/
https://ncbi.nlm.nih.gov/pubmed/28005533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2016.10.038
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