Progranulin Recruits HSP70 to β-Glucocerebrosidase and Is Therapeutic Against Gaucher Disease

Gaucher disease (GD), the most common lysosomal storage disease, is caused by mutations in GBA1 encoding of β-glucocerebrosidase (GCase). Recently it was reported that progranulin (PGRN) insufficiency and deficiency associated with GD in human and mice, respectively. However the underlying mechanism...

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Bibliografiska uppgifter
I publikationen:EBioMedicine
Huvudupphovsmän: Jian, Jinlong, Tian, Qing-Yun, Hettinghouse, Aubryanna, Zhao, Shuai, Liu, Helen, Wei, Jianlu, Grunig, Gabriele, Zhang, Wujuan, Setchell, Kenneth D.R., Sun, Ying, Overkleeft, Herman S., Chan, Gerald L., Liu, Chuan-ju
Materialtyp: Artigo
Språk:Inglês
Publicerad: Elsevier 2016
Ämnen:
Research Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5264254/
https://ncbi.nlm.nih.gov/pubmed/27789271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2016.10.010
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