Lentiviral CRISPR/Cas9 vector mediated miR-21 gene editing inhibits the epithelial to mesenchymal transition in ovarian cancer cells

CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats) mediated genome editing is a powerful approach for loss of function studies. Here we report that lentiviral CRISPR/Cas9 vectors are highly efficient in introducing mutations in the precursor miRNA sequence, thus leading to the l...

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Bibliographische Detailangaben
Veröffentlicht in:J Cancer
Hauptverfasser: Huo, Wenying, Zhao, Guannan, Yin, Jinggang, Ouyang, Xuan, Wang, Yinan, Yang, Chuanhe, Wang, Baojing, Dong, Peixin, Wang, Zhixiang, Watari, Hidemichi, Chaum, Edward, Pfeffer, Lawrence M., Yue, Junming
Format: Artigo
Sprache:Inglês
Veröffentlicht: Ivyspring International Publisher 2017
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5264040/
https://ncbi.nlm.nih.gov/pubmed/28123598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/jca.16723
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