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Coupled Proliferation and Apoptosis Maintain the Rapid Turnover of Microglia in the Adult Brain

Microglia play key roles in brain development, homeostasis, and function, and it is widely assumed that the adult population is long lived and maintained by self-renewal. However, the precise temporal and spatial dynamics of the microglial population are unknown. We show in mice and humans that the...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Askew, Katharine, Li, Kaizhen, Olmos-Alonso, Adrian, Garcia-Moreno, Fernando, Liang, Yajie, Richardson, Philippa, Tipton, Tom, Chapman, Mark A., Riecken, Kristoffer, Beccari, Sol, Sierra, Amanda, Molnár, Zoltán, Cragg, Mark S., Garaschuk, Olga, Perry, V. Hugh, Gomez-Nicola, Diego
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5263237/
https://ncbi.nlm.nih.gov/pubmed/28076784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.12.041
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