Effect of ex vivo expanded recipient regulatory T cells on hematopoietic chimerism and kidney allograft tolerance across MHC barriers in cynomolgus macaques

BACKGROUND: Infusion of recipient regulatory T cells (Treg) promotes durable mixed hematopoietic chimerism and allograft tolerance in mice receiving allogeneic BMT with minimal conditioning. We applied this strategy in a Cynomolgus macaque model. METHODS: CD4+CD25high Treg that were polyclonally exp...

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Veröffentlicht in:Transplantation
Hauptverfasser: Duran-Struuck, Raimon, Sondermeijer, Hugo P, Bühler, Leo, Alonso-Guallart, Paula, Zitsman, Jonah, Kato, Yojiro, Wu, Anette, McMurchy, Alicia N., Woodland, David, Griesemer, Adam, Martinez, Mercedes, Boskovic, Svetlan, Kawai, Tatsuo, Cosimi, A. Benedict, Wuu, Cheng-Shie, Slate, Andrea, Mapara, Markus, Baker, Sam, Tokarz, Rafal, D'Agati, Vivette, Hammer, Scott, Pereira, Marcus, Lipkin, W. Ian, Wekerle, Thomas, Levings, Megan, Sykes, Megan
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5263090/
https://ncbi.nlm.nih.gov/pubmed/27846155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/TP.0000000000001559
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