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A phase I trial of temsirolimus and pemetrexed in patients with advanced non-small cell lung cancer
BACKGROUND: Pemetrexed is an anti-folate chemotherapeutic agent approved for use in non-small cell lung cancer. Mammalian target of rapamycin (mTOR) pathway is implicated in lung cancer development, and is inhibited by temsirolimus. METHODS: We performed a phase I study evaluating the combination of...
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| Publié dans: | Chemotherapy |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5263044/ https://ncbi.nlm.nih.gov/pubmed/26780363 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000442147 |
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