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A phase I trial of temsirolimus and pemetrexed in patients with advanced non-small cell lung cancer

BACKGROUND: Pemetrexed is an anti-folate chemotherapeutic agent approved for use in non-small cell lung cancer. Mammalian target of rapamycin (mTOR) pathway is implicated in lung cancer development, and is inhibited by temsirolimus. METHODS: We performed a phase I study evaluating the combination of...

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Publicado en:Chemotherapy
Autores principales: Waqar, Saiama N., Baggstrom, Maria Q., Morgensztern, Daniel, Williams, Kristina, Rigden, Caron, Govindan, Ramaswamy
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5263044/
https://ncbi.nlm.nih.gov/pubmed/26780363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000442147
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