Sensitivity of GBM cells to cAMP agonist-mediated apoptosis correlates with CD44 expression and agonist resistance with MAPK signaling

In some cell types, activation of the second messenger cAMP leads to increased expression of proapoptotic Bim and subsequent cell death. We demonstrate that suppression of the cAMP pathway is a common event across many cancers and that pharmacological activation of cAMP in glioblastoma (GBM) cells l...

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Veröffentlicht in:Cell Death Dis
Hauptverfasser: Daniel, Paul M, Filiz, Gulay, Mantamadiotis, Theo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5261024/
https://ncbi.nlm.nih.gov/pubmed/27906173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2016.393
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