Distinct outcomes of CRL–Nedd8 pathway inhibition reveal cancer cell plasticity

Inhibition of protein degradation by blocking Cullin-RING E3 ligases (CRLs) is a new approach in cancer therapy though of unknown risk because CRL inhibition may stabilize both oncoproteins and tumor suppressors. Probing CRLs in prostate cancer cells revealed a remarkable plasticity of cells with TM...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Rulina, Anastasia V, Mittler, Frédérique, Obeid, Patricia, Gerbaud, Sophie, Guyon, Laurent, Sulpice, Eric, Kermarrec, Frédérique, Assard, Nicole, Dolega, Monika E, Gidrol, Xavier, Balakirev, Maxim Y
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5261022/
https://ncbi.nlm.nih.gov/pubmed/27906189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2016.395
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