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Wss1 metalloprotease partners with Cdc48/Doa1 in processing genotoxic SUMO conjugates
Sumoylation during genotoxic stress regulates the composition of DNA repair complexes. The yeast metalloprotease Wss1 clears chromatin-bound sumoylated proteins. Wss1 and its mammalian analog, DVC1/Spartan, belong to minigluzincins family of proteases. Wss1 proteolytic activity is regulated by a cys...
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| Udgivet i: | eLife |
|---|---|
| Main Authors: | , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
eLife Sciences Publications, Ltd
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4559962/ https://ncbi.nlm.nih.gov/pubmed/26349035 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.06763 |
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