An unusual mechanism for resistance to the antibiotic coumermycin A1.
Bacterial DNA gyrases are type II topoisomerases made up of two A subunits and two B subunits. Coumarins are carbohydrate-containing antibiotics that inhibit topoisomerases II by competing with ATP for binding to the enzymes. High resistance to coumarins is produced in bacterial species by mutations...
שמור ב:
| הוצא לאור ב: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
National Academy of Sciences
1991
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC52610/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1656457/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.19.8860 |
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