An unusual mechanism for resistance to the antibiotic coumermycin A1.

Bacterial DNA gyrases are type II topoisomerases made up of two A subunits and two B subunits. Coumarins are carbohydrate-containing antibiotics that inhibit topoisomerases II by competing with ATP for binding to the enzymes. High resistance to coumarins is produced in bacterial species by mutations...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	del Castillo, I, Vizán, J L, Rodríguez-Sáinz, M C, Moreno, F
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1991
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC52610/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1656457/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.19.8860
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