An unusual mechanism for resistance to the antibiotic coumermycin A1.

Bacterial DNA gyrases are type II topoisomerases made up of two A subunits and two B subunits. Coumarins are carbohydrate-containing antibiotics that inhibit topoisomerases II by competing with ATP for binding to the enzymes. High resistance to coumarins is produced in bacterial species by mutations...

Полное описание

Библиографические подробности

Опубликовано в::	Proc Natl Acad Sci U S A
Главные авторы:	del Castillo, I, Vizán, J L, Rodríguez-Sáinz, M C, Moreno, F
Формат:	Artigo
Язык:	Inglês
Опубликовано:	National Academy of Sciences 1991
Предметы:	Research Article
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC52610/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1656457/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.19.8860
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