Systemic application of 3-methyladenine markedly inhibited atherosclerotic lesion in ApoE(−/−) mice by modulating autophagy, foam cell formation and immune-negative molecules

A growing body of evidence demonstrates that autophagy, an evolutionarily conserved intracellular degradation process, is involved in the pathogenesis of atherosclerosis and has become a potential therapeutic target. Here we tested the effect of two inhibitors of phosphatidylinositol 3-kinase, 3-met...

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Bibliographische Detailangaben
Veröffentlicht in:Cell Death Dis
Hauptverfasser: Dai, Shen, Wang, Bo, Li, Wen, Wang, Liyang, Song, Xingguo, Guo, Chun, Li, Yulan, Liu, Fengming, Zhu, Faliang, Wang, Qun, Wang, Xiaoyan, Shi, Yongyu, Wang, Jianing, Zhao, Wei, Zhang, Lining
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5260998/
https://ncbi.nlm.nih.gov/pubmed/27906187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2016.376
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