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Hyperhomocysteinemia causes ER stress and impaired autophagy that is reversed by Vitamin B supplementation
Hyperhomocysteinemia (HHcy) is a well-known risk factor for stroke; however, its underlying molecular mechanism remains unclear. Using both mouse and cell culture models, we have provided evidence that impairment of autophagy has a central role in HHcy-induced cellular injury in the mouse brain. We...
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| Publié dans: | Cell Death Dis |
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| Auteurs principaux: | , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5260994/ https://ncbi.nlm.nih.gov/pubmed/27929536 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2016.374 |
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