Hyperhomocysteinemia causes ER stress and impaired autophagy that is reversed by Vitamin B supplementation

Hyperhomocysteinemia (HHcy) is a well-known risk factor for stroke; however, its underlying molecular mechanism remains unclear. Using both mouse and cell culture models, we have provided evidence that impairment of autophagy has a central role in HHcy-induced cellular injury in the mouse brain. We...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Tripathi, Madhulika, Zhang, Cheng Wu, Singh, Brijesh Kumar, Sinha, Rohit Anthony, Moe, Kyaw Thu, DeSilva, Deidre Anne, Yen, Paul Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5260994/
https://ncbi.nlm.nih.gov/pubmed/27929536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2016.374
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