Doxorubicin attenuates CHIP-guarded HSF1 nuclear translocation and protein stability to trigger IGF-IIR-dependent cardiomyocyte death

Doxorubicin (DOX) is one of the most effective antitumor drugs, but its cardiotoxicity has been a major concern for its use in cancer therapy for decades. Although DOX-induced cardiotoxicity has been investigated, the underlying mechanisms responsible for this cardiotoxicity have not been completely...

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Dettagli Bibliografici
Pubblicato in:Cell Death Dis
Autori principali: Huang, Chih-Yang, Kuo, Wei-Wen, Lo, Jeng-Fan, Ho, Tsung-Jung, Pai, Pei-ying, Chiang, Shu-Fen, Chen, Pei-Yu, Tsai, Fu-Jen, Tsai, Chang-Hai
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5260882/
https://ncbi.nlm.nih.gov/pubmed/27809308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2016.356
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