C66 ameliorates diabetic nephropathy in mice by both upregulating NRF2 function via increase in miR-200a and inhibiting miR-21

AIMS/HYPOTHESIS: Diabetic nephropathy is the leading cause of end-stage renal disease. Previously we reported that C66, a novel analogue of curcumin with a very high bioavailability, ameliorated diabetic nephropathy in mice, with little known about the mechanism. The present study aimed to define th...

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Veröffentlicht in:Diabetologia
Hauptverfasser: Wu, Hao, Kong, Lili, Tan, Yi, Epstein, Paul N., Zeng, Jun, Gu, Junlian, Liang, Guang, Kong, Maiying, Chen, Xiangmei, Miao, Lining, Cai, Lu
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5260795/
https://ncbi.nlm.nih.gov/pubmed/27115417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-016-3958-8
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