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Sitagliptin ameliorates oxidative stress in experimental diabetic nephropathy by diminishing the miR-200a/Keap-1/Nrf2 antioxidant pathway

BACKGROUND: Sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor used in type 2 diabetes therapy, has demonstrated protective effects in diabetic chronic kidney disease, in part due to its pleiotropic actions. However, its potential direct effects on the kidney are still not completely defined. H...

Täydet tiedot

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Bibliografiset tiedot
Julkaisussa:Diabetes Metab Syndr Obes
Päätekijät: Civantos, Esther, Bosch, Enrique, Ramirez, Elisa, Zhenyukh, Olha, Egido, Jesús, Lorenzo, Oscar, Mas, Sebastián
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Dove Medical Press 2017
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5473486/
https://ncbi.nlm.nih.gov/pubmed/28652790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DMSO.S132537
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