Deficiency of Parkinson's disease-related gene Fbxo7 is associated with impaired mitochondrial metabolism by PARP activation

The Parkinson's disease (PD)-related protein F-box only protein 7 (Fbxo7) is the substrate-recognition component of the Skp1-Cullin-F-box protein E3 ubiquitin ligase complex. We have recently shown that PD-associated mutations in Fbxo7 disrupt mitochondrial autophagy (mitophagy), suggesting a r...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Cell Death Differ
Main Authors: Delgado-Camprubi, Marta, Esteras, Noemi, Soutar, Marc PM, Plun-Favreau, Helene, Abramov, Andrey Y
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2017
Teme:
Original Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5260490/
https://ncbi.nlm.nih.gov/pubmed/27689878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2016.104
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