Computer prediction of paratope on antithrombotic antibody 10B12 and epitope on platelet glycoprotein VI via molecular dynamics simulation

BACKGROUND: Interaction between immunoglobulin-like receptor glycoprotein VI (GPVI) and collagen plays a central role in platelet activation and sequent firm adhesion. Of various antithrombotic agents targeting GPVI, antibody 10B12 is of great potential to block the GPVI-collagen interaction, but le...

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Bibliographic Details
Published in:Biomed Eng Online
Main Authors: Liu, Wenping, Liu, Guangjian, Zhou, Huiyun, Fang, Xiang, Fang, Ying, Wu, Jianhua
Format: Artigo
Language:Inglês
Published: BioMed Central 2016
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5260068/
https://ncbi.nlm.nih.gov/pubmed/28155721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12938-016-0272-0
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