Glucose Driven Changes in Beta Cell Identity Are Important for Function and Possibly Autoimmune Vulnerability during the Progression of Type 1 Diabetes

This commentary explores the hypothesis that when autoimmunity leads to a fall of beta cell mass during the progression of type 1 diabetes (T1D), rising glucose levels cause major changes in beta cell identity. This then leads to profound changes in secretory function and less well-understood change...

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Bibliographic Details
Published in:Front Genet
Main Authors: Weir, Gordon C., Bonner-Weir, Susan
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2017
Subjects:
Genetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5258704/
https://ncbi.nlm.nih.gov/pubmed/28174593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2017.00002
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