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Rational design, fabrication, characterization and in vitro testing of biodegradable microparticles that generate targeted and sustained transgene expression in HepG2 liver cells
Poly (lactide-co-glycolide) (PLGA) microparticles have significant potential for sustained delivery of plasmid DNA. However, unmodified PLGA microparticles have poor transfection efficiencies. In this study, we use several approaches to enhance the transfection efficiencies of PLGA microparticles in...
Enregistré dans:
| Publié dans: | J Drug Target |
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| Auteurs principaux: | , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2010
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5258116/ https://ncbi.nlm.nih.gov/pubmed/20681752 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/1061186X.2010.504263 |
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