Mechanistic aspects of the opposing effects of monoclonal antibodies to the ERBB2 receptor on tumor growth.

The ERBB2 (also called HER2, neu, and c-erbB-2) gene product, which encodes a growth factor receptor, was implicated in the malignancy of human adenocarcinomas. An antibody directed to the rat oncogenic receptor has been previously shown to have an antitumor effect in model systems. In an attempt to...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Stancovski, I, Hurwitz, E, Leitner, O, Ullrich, A, Yarden, Y, Sela, M
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1991
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC52575/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1717984/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.19.8691
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