Mechanistic aspects of the opposing effects of monoclonal antibodies to the ERBB2 receptor on tumor growth.

The ERBB2 (also called HER2, neu, and c-erbB-2) gene product, which encodes a growth factor receptor, was implicated in the malignancy of human adenocarcinomas. An antibody directed to the rat oncogenic receptor has been previously shown to have an antitumor effect in model systems. In an attempt to...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Stancovski, I, Hurwitz, E, Leitner, O, Ullrich, A, Yarden, Y, Sela, M
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1991
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC52575/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1717984/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.19.8691
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