Glycolysis and glutaminolysis cooperatively control T cell function by limiting metabolite supply to N-glycosylation

Rapidly proliferating cells switch from oxidative phosphorylation to aerobic glycolysis plus glutaminolysis, markedly increasing glucose and glutamine catabolism. Although Otto Warburg first described aerobic glycolysis in cancer cells >90 years ago, the primary purpose of this metabolic switch r...

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Bibliographic Details
Published in:eLife
Main Authors: Araujo, Lindsey, Khim, Phillip, Mkhikian, Haik, Mortales, Christie-Lynn, Demetriou, Michael
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2017
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5257256/
https://ncbi.nlm.nih.gov/pubmed/28059703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.21330
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