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High-fat diet-induced glucose dysregulation is independent of changes in islet ACE2 in mice
While restoration of ACE2 activity in the pancreas leads to improvement of glycemia in experimental models of Type 2 diabetes, global deficiency in ACE2 disrupts β-cell function and impairs glucose tolerance in mice, demonstrating the physiological role of ACE2 in glucose homeostasis. Although the c...
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| Udgivet i: | Am J Physiol Regul Integr Comp Physiol |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Physiological Society
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5256982/ https://ncbi.nlm.nih.gov/pubmed/27806985 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.00362.2016 |
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