Importance of specific purine amino and hydroxyl groups for efficient cleavage by a hammerhead ribozyme.
Eight modified ribozymes of 19 residues have been prepared with individual purine amino or hydroxyl groups excised. The modified ribozymes were chemically synthesized with the substitution of a single 2'-deoxyadenosine, 2'-deoxyguanosine, inosine, or purine riboside for residues G10, A11, G13, or A1...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1992
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC525616/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1570323/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.9.3985 |
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