Anti-myeloperoxidase antibodies attenuate the monocyte response to LPS and shape macrophage development

Anti-neutrophil cytoplasmic antibody (ANCA) vasculitis is characterized by the presence of autoantibodies to myeloperoxidase and proteinase-3, which bind monocytes in addition to neutrophils. While a pathological effect on neutrophils is acknowledged, the impact of ANCA on monocyte function is less...

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Publicado en:JCI Insight
Autores principales: Popat, Reena J., Hakki, Seran, Thakker, Alpesh, Coughlan, Alice M., Watson, Julie, Little, Mark A., Spickett, Corinne M., Lavender, Paul, Afzali, Behdad, Kemper, Claudia, Robson, Michael G.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2017
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5256146/
https://ncbi.nlm.nih.gov/pubmed/28138552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.87379
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