Oligonucleotide-mediated triple helix formation using an N3-protonated deoxycytidine analog exhibiting pH-independent binding within the physiological range.

Triple helix formation with pyrimidine deoxyoligonucleotides for the sequence-specific recognition of DNA duplex targets suffers from a decrease in affinity as the pH of the medium increases to that of physiological fluids. A solution to this problem has been identified and entails the substitution...

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Detaylı Bibliyografya
Asıl Yazarlar: Krawczyk, S H, Milligan, J F, Wadwani, S, Moulds, C, Froehler, B C, Matteucci, M D
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 1992
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC525570/
https://ncbi.nlm.nih.gov/pubmed/1570294
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