Gpr132 sensing of lactate mediates tumor–macrophage interplay to promote breast cancer metastasis

Macrophages are prominent immune cells in the tumor microenvironment that exert potent effects on cancer metastasis. However, the signals and receivers for the tumor–macrophage communication remain enigmatic. Here, we show that G protein-coupled receptor 132 (Gpr132) functions as a key macrophage se...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Chen, Peiwen, Zuo, Hao, Xiong, Hu, Kolar, Matthew J., Chu, Qian, Saghatelian, Alan, Siegwart, Daniel J., Wan, Yihong
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2017
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5255630/
https://ncbi.nlm.nih.gov/pubmed/28049847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1614035114
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