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Gpr132 sensing of lactate mediates tumor–macrophage interplay to promote breast cancer metastasis
Macrophages are prominent immune cells in the tumor microenvironment that exert potent effects on cancer metastasis. However, the signals and receivers for the tumor–macrophage communication remain enigmatic. Here, we show that G protein-coupled receptor 132 (Gpr132) functions as a key macrophage se...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5255630/ https://ncbi.nlm.nih.gov/pubmed/28049847 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1614035114 |
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