Molecular cloning and expression of human myocardial cGMP-inhibited cAMP phosphodiesterase.

We have cloned a cDNA for a myocardial cGMP-inhibited cAMP phosphodiesterase (cGI PDE) from a human heart cDNA library in lambda Zap II. The open reading frame [3.5 kilobases (kb)] of cDNA clone n.13.2 (7.7 kb) encodes a protein of 125 kDa. In Northern blots of total human ventricle RNA, a single mR...

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Bibliographic Details
Main Authors: Meacci, E, Taira, M, Moos, M, Smith, C J, Movsesian, M A, Degerman, E, Belfrage, P, Manganiello, V
Format: Artigo
Language:Inglês
Published: 1992
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC525562/
https://ncbi.nlm.nih.gov/pubmed/1315035
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