Molecular cloning and expression of human myocardial cGMP-inhibited cAMP phosphodiesterase.

We have cloned a cDNA for a myocardial cGMP-inhibited cAMP phosphodiesterase (cGI PDE) from a human heart cDNA library in lambda Zap II. The open reading frame [3.5 kilobases (kb)] of cDNA clone n.13.2 (7.7 kb) encodes a protein of 125 kDa. In Northern blots of total human ventricle RNA, a single mR...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Meacci, E, Taira, M, Moos, M, Smith, C J, Movsesian, M A, Degerman, E, Belfrage, P, Manganiello, V
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1992
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC525562/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1315035/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.9.3721
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